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Haematological and Biochemical Effects of Sulphadimidine in Nigerian Mongrel Dog

By Animal Research International, University Of Nigeria, Nsukka.

Summary

The systemic availability of a drug is the amount of administered drug which reaches the systemic circulation intact (Graham-Smith and Aronson, 1992). Measurement of drug concentration in the blood and urine are performed to determine the need for adjustment of the dosage or of the schedule of administration (Saganuwan et al., 2003).
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Abstract

ABSTRACT
Haematological and biochemical efects of sulphadmidine were studied in Nigerian mongrel dogs. Five Nigerian mongrel dogs of either sex weighing between 7 and 12 kg were used for the study. The pretreatment blood and serum samples were collected and the weight of animals taken before the administraton of 100 mg/kg body weight for a period of 7 days. The animals were weighed daily. The results showed that there was no significant difference between preadministraton and post administration weights (P>0.05) of dogs. Packed cell voume decreased significantly (P < 0.05) with duration sampled dogs. Liver function test revealed significant decrease (P < 005) o total bilirubin and alkaline phosphatase. Other indices of liver functon and electrolytes indices were normal (P > 0.05). The mean weight gain (8.8 ± 2.04 kga) of the animals before sulphadimidine administration was comparabe wth the weght gan (8.77 ± 0.89 kgb) of animals after the sulphadimidine administration. Sulphadimidine caused anaemia of moderate value (26.4 ±3.36%a) in the treated samples as compared to pretreated samples (46.4±6.27b). Total bilirubin (12.32 ±14μmola) in pretreatment samples was decreased in comparison with treated (18.5 ±2.0 αmol/lb) samples. Alkalne phosphatase was decreased in preadministration samples (114.2 ±5.7μg/lb) as compared to post administration sampes (130 ±9.61 μmol/la). Therefore longtime administration of sulphadimidine in anaemic mongrel dogs may aggravate anaemic condition. Sulphadimidine may increase renal excretion of bilirubin and decrease bone mineralization in mongrel dogs during bone formation.

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