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Effects of Oral Administration of Monosodium Glutamate (Msg) on Serum Testosterone Levels and Muscle Mass Development in Male Rats

By Animal Research International, University Of Nigeria, Nsukka.

Summary

The effects of oral administration of monosodum glutamate (MSG), a food additive andflavour enhancer, on serum testosterone levels and muscle mass development was studied using 28 four-week-old male rats. Treatment with MSG was accomplished by oral administration of increasing doses (1mg/g body weight, 2mg/g body weight and 4mg/gbody weight) of a 40% aqueous solution of monosodium glutamate to the male rats every 48 hours for 6 weeks, using a rat gavage needle. The results showed that MSG administration gave rise to significantly lowered serum testosterone levels (P<0.05), as well as significant reduction in the weight of skeletal muscles (P<0.05) when comparedto controls. However, the muscle mass indices (milligram muscle weight per gram body weight) of the muscles studied did not differ significantly (P>0.05) between MSG-treated rats and control rats. These results indicate that MSG may have disrupted the hypothalamic-pituitary-testes regulatory axis that controls testosterone production, and so resulted in lowered serum testosterone leves and loss or considerabe reduction in the stimulatory influence of testosterone on skeletal muscle growth.
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