Effects of Oral Administration of Monosodium Glutamate (Msg) on Serum Testosterone Levels and Muscle Mass Development in Male Rats
The effects of oral administration of monosodum glutamate (MSG), a food additive andflavour enhancer, on serum testosterone levels and muscle mass development was studied using 28 four-week-old male rats. Treatment with MSG was accomplished by oral administration of increasing doses (1mg/g body weight, 2mg/g body weight and 4mg/gbody weight) of a 40% aqueous solution of monosodium glutamate to the male rats every 48 hours for 6 weeks, using a rat gavage needle. The results showed that MSG administration gave rise to significantly lowered serum testosterone levels (P<0.05), as well as significant reduction in the weight of skeletal muscles (P<0.05) when comparedto controls. However, the muscle mass indices (milligram muscle weight per gram body weight) of the muscles studied did not differ significantly (P>0.05) between MSG-treated rats and control rats. These results indicate that MSG may have disrupted the hypothalamic-pituitary-testes regulatory axis that controls testosterone production, and so resulted in lowered serum testosterone leves and loss or considerabe reduction in the stimulatory influence of testosterone on skeletal muscle growth.
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