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Antagonistic Effects of Ceftriaxone and Sulphadimidine on Ketamine and Thiopentone Anaesthetics in Nigerian Local Dog

By Animal Research International, University Of Nigeria, Nsukka.


Antagonistic effects of ce triaxone and sulphadimidine on ketamine and thiopentone anaesthetics were studied in Nigerian local dogs. Twenty – four N gerian local dogs were used for the study. The dogs were divided into s x groups: A, B, C, D E, and F, with four dogs per group. Groups A and B were intravenously administered 17 mg/kg and 20 mg/kg body weight f thiopentone and ketamine respect vely. But groups C and D were administered 23 mg/kg and 100mg/kg body weight of ceftriaxone and sulphadimidine respectively in addition to 20 mg/kg body weight of ketamine. However, groups E and F were administered intravenous dose of 23 mg/kg and 100 mg/kg of ceftriaxone and sulphadimidine respectively in addition to 17 mg/kg weight body of thiopentone. Vital parameters such as determination of anesthesia; onset and duration, temperature, respiratory and heart rates were recorded. The results of onset of duration of anesthesia revealed significant difference (P< 0.05) among group E, F and A animals. Although the result of onset anesthesia revealed significant difference between group A and B animals (P < 0.05). The values of respiratory rate revealed significant difference between the animals in groups D and B as well as groups F and A (P < 0.05). The values of heart rate showed significant difference between group C and D animals as well as between E and A animals (P < 0.05). Conclusively, sulphadimid ne and cerftriaxone caused decreased duration of both anesthesia and onset of anesthesia when either was coadministered with ketamine or thiopentone in Nigerian local dogs. Sulphad midine also caused increased respiratory rate, but cerftriaxone caused decreased and increased heart rate if coadministered with ketamine and thiopentone respectively..."
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